Horizon Scanning in Oncology - Reports

Decision Support Documents
Within the scope of the Horizon Scanning in Oncology project, the LBI-HTA periodically publishes assessments on novel cancer drugs with a likely therapeutical and/or financial outcome. These assessments serve as decision aids for funding agencies and the decision-making network "HTA in hospitals " alike.
Publication series (in English):
DSD HSO No 91
DSD HSO No. 90
DSD HSO No. 89
Brentuximab vedotin (Adcetris®) in combination with chemotherapy for CD30-positive peripheral T-cell lymphoma (PTCLs)
DSD HSO No. 88
Darolutamide for the treatment of patients with nonmetastatic castration-resistant prostate cancer (CRPC)
DSD HSO No. 87
Atezolizumab (Tecentriq®) with nab-paclitaxel (Abraxane®) for the treatment of advanced triple-negative breast cancer (aTNBC)
DSD HSO No. 86
Olaparib (Lynparza®) as first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer'
DSD HSO No. 85
Ibrutinib (Imbruvica®) in combination with rituximab for the treatment of Waldenström’s macroglobulinemia
DSD HSO No. 84
Enzalutamide (Xtandi®) in patients with nonmetastatic, castration-resistant prostate cancer (CRPC)
DSD HSO No. 83
Pembrolizumab (Keytruda®) in combination with chemotherapy for the treatment of metastatic non-small-cell lung cancer (NSCLC)
DSD HSO No. 82
Nivolumab (Opdivo®) in combination with ipilimumab (Yervoy®) for the first-line treatment of patients with advanced RCC
DSD HSO No. 81
Daratumumab (Darzalex®) in combination with bortezomib, melphalan and prednisone for untreated myeloma
DSD HSO No. 80
Osimertinib (Tagrisso®) for the initial treatment of EGFR-mutated advanced non–small-cell lung cancer (NSCLC) New!
DSD HSO No. 79
Rituximab (MabThera®) after autologous stem-cell transplantation (ASCT) in mantle cell lymphoma (MCL)
DSD HSO No. 77
Alectinib as monotherapy for the first-line treatment of adult patients with ALK-positive advanced non-small cell lung cancer (NSCLC)
DSD HSO No. 76
Durvalumab (Imfinzi™) for the treatment of patients with stage III non-small-cell lung cancer after prior chemoradiotherapy
DSD HSO No. 74
Midostaurin with standard chemotherapy in FLT3-Positive Acute Myeloid Leukaemia
DSD HSO No. 72
Abemaciclib (Verzenio®) in combination with fulvestrant for treatment of HR-positive, HER2-negative advanced breast cancer (ABC)
DSD HSO No. 71
Olaparib (Lynparza®) in patients with BRCA-mutated metastatic breast cancer
DSD HSO No. 70
Pembrolizumab (Keytruda®) as second-line treatment for patients with advanced urothelial carcinoma (UC)
DSD HSO No. 69
Ceritinib (Zykadia®) as first-line therapy for patients with advanced ALK-positive non-small cell lung cancer
DSD HSO No. 68
Atezolizumab (Tecentriq®) in previously treated non-small cell lung cancer (NSCLC)
DSD HSO No. 67
Ipilimumab (Yervoy®) in the adjuvant therapy for high-risk stage III cutaneous melanoma
DSD HSO No. 66
Neratinib for the treatment of patients with HER2-positive breast cancer after trastuzumab-based adjuvant therapy
DSD HSO No. 65
Ribociclib in combination with letrozole for the first-line therapy of HR-positive, HER2-negative recurrent or metastatic breast cancer
DSD HSO No. 63
Ixazomib (Ninlaro®) in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma (MM)
DSD HSO No. 62
Venetoclax (VenclextaTM) for the treatment of relapsed or refractory chronic lymphocytic leukaemia (CLL) with chromosome 17p deletion
DSD HSO No. 61
Atezolizumab (TecentriqTM) for the treatment of locally advanced and metastatic urothelial carcinoma
DSD HSO No. 60
Obinutuzumab (Gazyvaro®) in combination with bendamustine for the treatment of relapsed/refractory follicular lymphoma (FL)
DSD HSO No. 58
Pembrolizumab (Keytruda®) in previously treated advanced non-small cell lung cancer (NSCLC)
DSD HSO No. 57
Ofatumumab (Arzerra®) as maintenance therapy in patients with relapsed chronic lymphocytic leukaemia (CLL)
DSD HSO No. 56
Bevacizumab (Avastin®) in addition to standard chemotherapy for the first-line treatment of ovarian cancer
DSD HSO No. 55
Pembrolizumab (Keytruda®) for the treatment of advanced melanoma
DSD HSO No. 53
Nivolumab (Nivolumab BMS®) for the second-line therapy of metastatic squamous non-small cell lung cancer
DSD HSO No. 52
Carfilzomib (Kyprolis®) for patients with relapsed multiple myeloma who have received one to three prior lines of therapy
DSD HSO No. 50
Nivolumab (Opdivo®) as single-agent first-line therapy for unresectable or metastatic melanoma
DSD HSO No. 49
Idelalisib (Zydelig®) in addition to rituximab for the treatment of relapsed chronic lymphocytic leukaemia
DSD HSO No. 48
Bevacizumab (Avastin®) for platinum-resistant recurrent, epithelial ovarian, fallopian tube or primary peritoneal cancer
DSD HSO No. 47
Ibrutinib (Imbruvica®) for relapsed or refractory chronic lymphocytic leukaemia
DSD HSO No. 46
Bevacizumab (Avastin®) as maintenance therapy after first progression on bevacizumab for patients with advanced colorectal carcinoma
DSD HSO No. 45
Obinutuzumab (Gazyva®) for previously untreated patients with chronic lymphocytic leukaemia (CLL)
DSD HSO No. 43
Nab-Paclitaxel (Abraxane®) as first-line therapy for metastatic adenocarcinoma of the pancreas
DSD HSO No. 40
Regorafenib (Stivarga®) for heavily pretreated patients with metastatic colorectal cancer (mCRC)
DSD HSO No. 39
Pomalidomide (Pomalyst®) for the ? 3rd-line therapy of patients with relapsed and refractory multiple myeloma
DSD HSO No. 38
Aflibercept (Zaltrap®) in addition to FOLFIRI for the 2nd line therapy of metastatic colorectal cancer
DSD HSO No. 36
Trastuzumab emtansine (KadcylaTM) for previously treated patients with
HER2-positive advanced/ metastatic breast cancer
DSD HSO No. 35
Crizotinib (Xalkori®) for the treatment of anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC)
DSD HSO No. 34
Trametinib for advanced or metastatic BRAF V600 mutation-positive melanoma
DSD HSO No. 33
Lenalidomide (Revlimid®) for the first-line therapy of transplant-ineligible patients with multiple myeloma
DSD HSO No. 31
Pertuzumab (Omnitarg/Perjeta®) for the first-line therapy of metastatic HER2 positive breast cancer
DSD HSO No. 30
Ipilimumab (Yervoy®) for the first-line therapy of advanced/metastatic cutaneous melanoma
DSD HSO No. 28
Lenalidomide (Revlimid®) for the treatment of low /intermediate-1 risk myelodysplastic syndrome with chromosome 5q deletion
DSD HSO No. 27
Bevacizumab (Avastin®) in combination with chemotherapy in previously treated metastatic breast cancer
DSD HSO No. 24
Everolimus (Afinitor®) for the treatment of unresectable or metastatic neuroendocrine tumours of pancreatic origin
DSD HSO No. 23
Vemurafenib for patients with BRAF V600E mutation positive advanced/metastatic melanoma
DSD HSO No. 21
Axitinib (AG013736, Inlyta®) for the second-line treatment of metastatic renal cell carcinoma (mRCC)
DSD HSO No. 19
S-1 (TeysunoTM) as first-line therapy for patients with advanced non-small cell lung cancer
DSD HSO No. 18
Eribulin (Halaven®) as third- or late- line mono-therapy for advanced/metastatic breast cancer
DSD HSO No. 17
Dasatinib (Sprycel®) for the 1st-line treatment of Philadelphia-chromosome positive chronic myeloid leukemia in the chronic phase
DSD HSO No. 16
Second-line chemotherapy with cabazitaxel (Jevtana®) for the treatment of castration-resistant metastatic prostate cancer
DSD HSO No. 15
Nilotinib (Tasigna®) for the 1st-line treatment of Philadelphia chromosome positive chronic myeloid leukemia in the chronic phase
DSD HSO No. 14
Ipilimumab for pre-treated patients with advanced/metastatic melanoma
DSD HSO No. 13
Pazopanib (Votrient®) for the treatment of locally advanced and/or metastatic renal cell carcinoma
DSD HSO No. 12
Trastuzumab (Herceptin®) in addition to standard chemotherapy as first-line therapy for advanced gastric cancer
DSD HSO No. 11
Panitumumab (Vectibix®) for the first-line treatment of metastatic colorectal cancer
DSD HSO No. 11/ 1st update 2011
Panitumumab (Vectibix®) as 1st-line combination therapy for the treatment of WT KRAS metastatic colorectal cancer
DSD HSO No. 9
Lapatinib ditosylate (Tyverb/Tykerb®) as first-line therapy for the treatment of advanced/metastatic breast cancer
DSD HSO No. 8
Plerixafor (Mozobil®) for autologous stem cell transplantation in patients with lymphoma and multiple myeloma
DSD HSO No. 7
Trabectedin (Yondelis®) for second-line recurrent platinum-sensitive ovarian cancer
DSD HSO No. 6
Gefitinib (Iressa®) for the first-line treatment of non-small cell lung cancer
DSD HSO No. 6/ 1st update 2011
Gefitinib (Iressa®) for the 1st-line treatment of non-small cell lung cancer – 1st Update 2011
DSD HSO No. 5
Ibritumomab tiuxetan (Zevalin®) as consolidation therapy after first remission in patients with follicular lymphoma
DSD HSO No. 4
Rituximab (Rituxan®/MabThera®) for the first- and second-line treatment of chronic lymphocytic leukaemia
DSD HSO No.4/ 1st update 2011
Rituximab (Rituxan®/MabThera®) for the first- and second-line treatment of chronic lymphocytic leukaemia – 1st Update 2011
DSD HSO No. 3
Everolimus (Afinitor®) for the treatment of advanced/metastatic kidney cancer
DSD HSO No. 2
Cetuximab (Erbitux®) in EGFR-expressing Non-Small Cell Lung Cancer
DSD HSO No. 1
Azacitidine (Vidaza®) for the treatment of myelodysplastic syndromes
Contact: Nicole Grössmann