Welcome to the homepage of LBI-HTA !
The LBI-HTA is an acadmic non-profit institute and belongs to the Ludwig Boltzmann Society. At our website we wish to present our research and give support for health care decision-making. Here all of our reports are available for free. For further information please contact the LBI-HTA team.
Hardly any other medical technology has been evaluated as often in the western countries as positron emission tomography (PET/PET-CT): this is an expression of uncertainty about the value of PET diagnostics in the care of patients. The present HTA report updates the evidence on oncological indications and adds neurological indications and inflammatory diseases to the LBI-HTA report from 2015. The report was conducted in cooperation between the TU Berlin and the LBI-HTA to provide an updated decision support for evidence-based PET/PET-CT planning in Germany and Austria.
Publication: LBI-HTA Project report No. 77/ Update: http://eprints.hta.lbg.ac.at/1178/
This Information is available in German only.
External stimulation of the trigeminal nerve for the prevention and acute treatment of episodic and chronic migraine
External trigeminal nerve stimulation (e-TNS) device produced by the manufacturer Cefaly is the intervention at stake. The mechanism of action is that e-TNS produces a micro-pulse on the upper branch of the trigeminal nerve (suborbital nerve) through an adhesive electrode that is placed on the forehead. The aim of the project is to perform a synthesis of evidence on the basis of a systematic literature search regarding effectiveness and safety of the e-TNS for the prevention and treatment of episodic and chronic migraine.
Publication: Decision Support Document No. 114: http://eprints.hta.lbg.ac.at/1177/
Contact: Michal Stanak
We are pleased to introduce our two new HSO reports.
Carbon ion beam radiotherapy (CIRT) for cancer treatment: a systematic review of effectiveness and safety for 12 oncologic indications.
The project aimed at elaborating possible cancer types, being an indication for carbon ion radiotherapy (CIRT). As such, clinical studies, analysing the use of CIRT for specific cancer types, were identified through a systematic literature search and were reviewed and reported in this project.
Furthermore, a systematic review on the effectiveness (mortality, morbidity) and safety of CIRT for 54 oncologic indications in 12 regions (i.e., skull base, eye, brain, ear-nose-throat, lung, gastrointestinal, bone and soft tissue, prostate, breast, kidney, nervous system, hematologic cancer) was conducted.
Publication: LBI-HTA Project report No. 101: http://eprints.hta.lbg.ac.at/1174/
Contact: Gregor Goetz
We are pleased to introduce our new reports.
Decison Support Documents 2018
DSD 109: Subcutaneous implantable cardioverter defibrillator (ICD)
DSD 110: Lymphovenous anastomoses in patients with primary and secondary lymphoedema
DSD 111: Allogeneic mesenchymal stem cells for Crohn’s disease-associated complex perianal fistulas
DSD 112: Meniscal allograft transplantation for post-meniscectomy syndrome
DSD 113: Baroreceptor activation therapy for treatment-resistant hypertension
+ 3 Updates
DSD 20/4. Update 2018: Endobronchial valve implantation for emphysema
DSD 37/1. Update 2018: High-intensity focused ultrasound for the treatment of prostate cancer
DSD 44/3. Update 2018: (Percutaneous) left atrial appendage closure for the prevention of thromboembolic events in patients with atrial fibrillation
Stereotactic radiotherapy, proton therapy and irreversible electroporation for the treatment of localized prostate cancer
Irreversible electroporation (IRE, NanoKnife®) is a type of focal therapy which has been suggested as an alternative to radical treatment. It typically uses 3 to 5 electrodes which deliver short repetitive electrical pulses to destroy the cancer cells. Stereotactic radiotherapy (stereotactic body radiation therapy or SBRT) is a type of external radiation in which a higher radiation dose is delivered in a reduced number of fractions as is the case with conventional or moderately fractionated radiation therapy. Proton therapy (PT) is a further type of external radiation therapy which uses high doses of ionizing rays directed at the tumour. There is at present inadequate and insufficient evidence to show that IRE, SBRT and PT have either a positive impact on survival and quality of life or the ability to prevent or delay prostatectomy.
Publication: LBI-HTA Project report No. 107: http://eprints.hta.lbg.ac.at/1165/
Contact: Claudia Wild